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Altered insulin signaling in the brainalso influences regulation of amyloid-? (A?) (Craft, 2007)and other AD biomarkers, such as BDNF (Gomez-Pinilla etal., 2008) and cortisol (Mastorakos and Pavlatou, 2005). Serological tests showednon detectable levels of antibodies

Serological tests showednon detectable levels of antibodies. Kovarsky (2008) argues that, in order to be effective, evidence-based practicemust reflect “the voices of those who are the potential beneficiaries of assessment andintervention.” Tetnowski and Franklin (2003) likewise advise practitioners to assess allinformation that will support decisions that “are most important or relevant to the indi-vidual under scrutiny.” It should be remembered that the ultimate aim of EBP is to pro-mote positive clinical or practical outcomes for each patient or client (Johnson, 2006).

In general, both the Kruskal-Wallis one-wayANOVA by ranks and the Friedman two-way ANOVA by ranks test the hypothesis thata number of samples (groups) have been drawn from the same population and hence havesimilar average values in rank. 2002 ),and other studies have shown that further pres-sure loss occurs between the prong and the phar-ynx (De Paoli et al.

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