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First, in-coming odorant molecules are solubilized in the olfactorymucus, and then OBPs act as molecular carriers that trans-port odorants and deliver them to the olfactory receptors(ORs) located in the plasma membrane of the cilia. This restriction may be related to dif-fuse in?ammatory obstruction of small airway anddoes not necessarily indicate more severe disease.It may be reversible in some (Ries et al. 1984 ;1999; Ciesla 1996; Oberwaldner 2000 ).
This step is often dif?cult because diagnostic labelsoverlap, making it hard to identify the most appropriate diag-nosis. Some medications interfere withthe process of sensory transduction (for example, by inter-fering directly with the receptor or its components, suchas G-proteins, adenylate cyclase, or receptor kinase); oth-ers interfere with neurotransmitters involved in olfactoryprocessing; and still others are directly toxic to olfactoryneuroepithelium or the nerves themselves. As a policy strategy, RDnational plan’s overall success heavily depends on the initial planning’s effectivenessand on the ?nal evaluation’s results As a policy strategy, RDnational plan’s overall success heavily depends on the initial planning’s effectivenessand on the ?nal evaluation’s results.
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